PhD thesis
2024
Lauritz Falkow Brorsen, Cand Scient Pharm, PhD, Dept. of Dermatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg

Preclinical Studies of Mass Spectrometry Techniques in Skin Cancer Management

Aim of the study

The research described in this thesis aims to evaluate the potential of MALDI-MSI as a technology for metabolomic characterization and clinical diagnosis of KC by comparison with histopathology.

Additionally, it seeks to establish a foundation for the future clinical implementation of a LA-REIMS system for real-time intraoperative tissue classification, thereby bridging the gap between molecular diagnostics and clinical treatment. This could provide a two-in-one approach combining diagnosis and treatment.

Research objectives

  1. Accurately identify SCC and BCC regions in tissue sections using MALDI-MSI and ML
  2. Characterize the metabolic profiles of SCC and BCC
  3. Development of a LA-REIMS system for imaging and treatment of KC

For copyright compliance reasons, the document on this page has been abbreviated to only include a list of papers and summaries in Danish and English.

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