Stine Regin Wiegell

Chief Physician, Associate Professor
Education
MD, DMSc, PhD
Work areas
Research, Teaching and Clinician
Telephone
Email
stine.regin.wiegell@regionh.dk
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Current workplace

Bispebjerg Hospital, Department of Dermatology
Nielsine Nielsens Vej 17, opg. 9, 2.sal D92
2400 Copenhagen NV.
Denmark

Current research                                    

For years I have done research in photodynamic therapy of actinic keratoses, acne and non-melanoma skin cancer. Together with Prof. Hans Christian Wulf I have simplified and improved the treatment of actinic keratoses by introduction of the concept daylight-mediated photodynamic therapy. Daylight photodynamic therapy is now used all over the world. We will now try to improve the efficacy of daylight PDT in thick actinic keratoses by combining the treatment with 5-fluorouracil cream. In the last years I have also worked with calcium electroporation of basal cell carcinomas in which an electrical field destabilizes the plasma membrane allowing influx of calcium leading to cell death.

Main interests

  • Photodynamic Therapy
  • Electroporation
  • Treatment of actinic keratoses and non-melanoma skin cancer
  • Diagnosis and treatment of photodermatoses

PhD thesis

Title:
Pain associated with photodynamic therapy – mechanisms and pain-reducing techniques

Enrollment:
University of Copenhagen

Year:
2008

Doctoral dissertation

Title:
Daylight-mediated photodynamic therapy

Enrollment:
University of Copenhagen

Year:
2014

Publications

Wiegell SR, Hædersdal M, Philipsen PA, Eriksen P, Enk CD, Wulf HC. Continuous activation of PpIX by daylight is as effective as and less painful than conventional PDT for actinic keratoses; a randomized, controlled, single-blinded study. Br J Dermatol. 2008 Apr;158(4):740-6.

Wiegell SR, Fabricius S, Stender IM, Berne B, Kroon S, Andersen BL, Mørk C, Sandberg C, Jemec GB, Mogensen M, Brocks KM, Philipsen PA, Heydenreich J, Haedersdal M, Wulf HC. A randomized, multi-center study of directed daylight exposure times of 1½ versus 2½ hours in daylight mediated photodynamic therapy with methyl aminolevulinate in patients with multiple thin actinic keratoses of the face and scalp. Br J Dermatol. 2011 May;164(5):1083-90.

Nissen CV, Heerfordt IM, Wiegell SR, Mikkelsen CS, Wulf HC. Pretreatment with 5-Fluorouracil Cream Enhances the Efficacy of Daylight-mediated Photodynamic Therapy for Actinic Keratosis. Acta Derm Venereol. 2017 May 8; 97(5):617-21.

Hendel K, Jemec GBE, Haedersdal M, Wiegell SR. Electrochemotherapy with bleomycin for basal cell carcinomas: A systematic review. J Eur Acad Dermatol Venereol. 2021 Jul 4. Online ahead of print.

 

Publications and releases

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