Uffe Høgh Olesen
Bispebjerg Hospital, Department of Dermatology
Nielsine Nielsens Vej 17, opg. 9, 2.floor D92
2400 Copenhagen NV.
Denmark
Current research
In recent years, my focus has been on facilitating topical delivery of drugs normally administered systemically (intravenously or perorally) using dermatological energy-based devices including ablative fractional laser and electronically-controlled pneumatic injection. Successful delivery drugs such as vismodegib, cisplatin, bleomycin and nivolumab aiming to treat keratinocyte cancer. My current research focus is on laser as an activator of the immune system to combat cancers locally. The impact of laser on the innate and adaptive immune responses and the potential for combination with immunotherapy is explored.
Main interests
- Laser-assisted drug delivery
- Laser-induced immunoactivation
- Translational research
Short description
PhD student supervisor: two current and two completed PhD projects
PhD thesis
Title:
Inhibitors of Nicotinamide Phosphoribosyltransferase in Cancer Treatment: Identification of Chemical Inhibitors, Cancer Resistance Mechanisms and Nicotinic Acid Cellular Rescue
Enrollment:
University of Copenhagen
Year:
2009
Publications
Fontenete S, Lerche CM, Paasch U, Perez-Moreno M, Olesen UH, Haedersdal M. Tumor Clearance and Immune Cell Recruitment in UV-Induced Murine Squamous Cell Carcinoma Exposed to Ablative Fractional Laser and Imiquimod Treatment. Lasers Surg Med. 2021 Apr 3. Online ahead of print.
Christensen RL, Omland SH, Persson DP, Husted S, Haedersdal M, Olesen UH. Topical Delivery of Nivolumab, a Therapeutic Antibody, by Fractional Laser and Pneumatic Injection. Lasers Surg Med. 2021 Jan;53(1):154-161.
Olesen UH, Clergeaud G, Hendel KK, Yeung K, Lerche CM, Andresen TL, Haedersdal M. Enhanced and Sustained Cutaneous Delivery of Vismodegib by Ablative Fractional Laser and Microemulsion Formulation. J Invest Dermatol. 2020 Oct;140(10):2051-2059.
Erlendsson AM, Olesen UH, Haedersdal M, Rossi AM. Ablative fractional laser-assisted treatments for keratinocyte carcinomas and its precursors-Clinical review and future perspectives. Adv Drug Deliv Rev. 2020 Jan 1;153:185-194.
Wenande E, Olesen UH, Boesen MR, Persson DP, Lerche CM, Stürup S, Gammelgaard B, Husted S, Anderson RR, Haedersdal M. Laser-assisted delivery enhances topical uptake of the anticancer agent cisplatin. Drug Deliv. 2018 Nov;25(1):1877-1885.
Publications and releases
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