Laser immunotherapy with and without topical anti-PD1 in basal cell carcinomas (BCC)
BCC is the most common malignancy with increasing incidence and demand for new treatment modalities.
There is increasing focus on the immune activating response to laser treatment. Combining laser with immunotherapeutic agents may further potentiate the immune activation.
The study aimed to assess the immunological and clinical response in BCC treated with ablative fractionated laser (AFL) as monotherapy and compare with BCC treated with combination-therapy of AFL and the anti-PD1-drug Nivolumab and with Nivolumab as monotherapy. Patients with BCC of the trunk or extremities were included and immunological response to treatment was investigated prior to and 1 week after treatment. Clinical response evaluated 3 months following treatment.
Researcher
MD, PhD Silje Haukali Omland
Project supervisors
Professor, MD, DMSC, PhD Merete Hædersdal
Senior researcher, PhD, Cand. scient. Human Biology Uffe Høgh Olesen
Project period
2019-2022
Project collaborators
Professor, MD, PhD Inge Marie Svane
MD, PhD Dorrit Krustrup
Financing
External funding
Selected publications
Omland SH, Ahlström MG, Gerstoft J, Pedersen G, Mohey R, Pedersen C, Kronborg G, Larsen CS, Kvinesdal B, Gniadecki R, Obel N, Omland LH. Risk of skin cancer in HIV-infected patients: a Danish nationwide cohort study. J Am Acad Dermatol. 2018 Oct;79(4):689-695.
Omland SH, Wettergren EE, Mollerup S, Asplund M, Mourier T, Hansen AJ, Gniadecki R. Cancer associated fibroblasts (CAFs) are activated in cutaneous basal cell carcinoma and in the peritumoural skin. BMC Cancer. 2017 Oct 7;17(1):675.
Omland SH, Hamrouni A, Gniadecki R. High Diversity of the T-cell receptor repertoire of tumor-infiltrating lymphocytes in basal cell carcinoma. Exp Derm. 2016;26(5):454-456.
Omland SH, Nielsen PS, Gjerdrum LMR, Gniadecki R. Immunosuppressive environment in basal cell carcinoma: the role of regulatory T-cells (T-regs). Acta Derm Venereol. 2016 Nov 2;96(7):917-921.
Omland SH, Gniadecki R, Hædersdal M, Helweg-Larsen J, Omland LH. Skin cancer risk in Danish haematopoietic stem cell transplant recipients compared with background population and renal transplant recipients: a population based cohort study. JAMA Dermatol. 2015 Oct 10:1-7.