Mass spectrometry-based analytical methods for quantification and identification of biological responses

The project seeks to identify and quantify drugs and biomarkers from biological samples by analysis with liquid chromatography-mass spectrometry (LC-MS) and other analytical methods. These analyses can either be performed to support other research projects or with a focus on developing of new analytical methods.

A primary goal of the project is to develop a robust method for quantification of dinucleotides that are excreted in urine following DNA damage. Other focus areas include analysis of vitamin D and vismodegib from different biological matrices.