Combination of Laser and Topical Hedgehog Inhibitor to treat Basal Cell Carcinoma in a Pre-Clinical Model

The PhD project consist of 3 pre-clinical studies: study 1 assesses whether ablative fractionated laser can be used to increase the skin concentration of topical HH inhibitors and enable us to treat BCC patients without the use of oral drugs. Study 2 investigates whether HH inhibitors can be used as a neoadjuvant to other approved BCC treatments (5-FU, cisplatin, curettage, etc.). Study 3 examines if the HH inhibitors can be used for prophylactic treatment by applying them before BCCs emerge. Altogether these 3 studies will result in important basic knowledge which will help us evaluate how HH inhibitors best can be used in a clinical setting.